{"id":1748,"system":{"id":43,"isbt_number":43,"name":"ABCC1","symbol":"ABCC1","category":"Blood Group System","approved":true,"version":2,"createdAt":"2024-04-29T09:32:40.126Z","updatedAt":"2025-09-24T11:12:33.789Z","description":"ABCC1 is also known as MRP1 “Multidrug Resistance Protein 1”. It was initially discovered in 1992 in a lung cancer cell line with a multidrug resistance phenotype(1). Cells with an increased expression show a resistance to drugs and xenobiotics. ABCC1 allows for the transport of various substrates involved in oxidative stress homeostasis, inflammation and nucleotide metabolism (efflux pump). In RBCs, ABCC1 has been described as an exporter of glutathione-S-conjugates and ATP.","allele_notes":"","assignees":["Thierry Peyrard"]},"gene":{"id":49,"name":"ABCC1","isbt_gene":"NG_028268.2","isbt_transcript":"NM_004996.4","isbt_protein":"NP_004987.2","approved":true,"createdAt":"2024-04-29T09:33:27.351Z","updatedAt":"2024-05-06T16:34:47.108Z","version":1,"initiation_codon":null,"stop_codon":null,"entrez_id":4363,"chromosome":"16","hg19_start":16043473,"hg19_end":16236910,"hg38_start":15949138,"hg38_end":16143257,"exon_count":31},"reference_allele":true,"sv_allele":false,"null_allele":false,"mod_allele":false,"partial_allele":false,"weak_allele":false,"el_allele":false,"allele_order":null,"isbt_allele":"ABCC1*01","alternate_names":null,"isbt_phenotype":"ABCC1:1, WLF+","isbt_snp":null,"table_row_group":null,"notes":null,"approved":true,"comment":null,"deleted":false,"obsolete":false,"provisional":false,"phenotypes":[{"id":17171,"phenotype":"+","approved":true,"predicted":false,"antigen":{"id":361,"isbt_code":"ABCC11","isbt_number":1,"name":"WLF","display_name":"WLF","search_terms":["WLF","043001"],"antigen_order":null,"approved":true,"provisional":false,"compound":false,"multigene":false,"prevalence":null,"createdAt":"2024-05-14T16:35:00.280Z","updatedAt":"2025-09-24T11:12:33.923Z","version":2},"createdAt":"2024-10-18T23:23:30.085Z","updatedAt":"2024-10-18T23:23:30.085Z","version":1}],"variants":[],"genbanks":[{"id":818,"accession":"NG_028268.2","definition":"Homo sapiens ATP binding cassette subfamily C member 1 (ABCC1 blood group) (ABCC1), RefSeqGene on chromosome 16","createdAt":"2024-09-29T14:40:25.511Z","updatedAt":"2024-09-29T14:40:25.511Z","version":1}],"publications":[{"id":641,"identifier":"1360704","citation":"Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science. 1992 Dec;5088(258):1650-4.","type":"pmid","createdAt":"2024-09-29T12:17:35.996Z","updatedAt":"2024-09-29T12:17:35.996Z","version":1}],"createdBy":{"username":"Nick Gleadall"},"updatedBy":{"username":"Nick Gleadall"},"createdAt":"2024-10-17T22:28:02.387Z","updatedAt":"2024-10-17T22:28:02.387Z","version":1}